Medical Mnemonics: Causes of Anion Gap Metabolic Acidosis – “GOLD MARK”

Causes of Anion Gap Acidosis can be remembered by the mnemonic "GOLD MARK" - Previously "MUDPILES"

Medical Mnemonics – Anion Gap Acidosis – “GOLD MARK”


The classic mnemonic often used to remember the causes of anion gap metabolic acidosis is “MUDPILES”
  • M – Methanol
  • U – Uremia
  • D – Diabetic ketoacidosis
  • P – Propylene Glycol
  • I – Isoniazid
  • L – Lactic Acidosis
  • E – Ethylene Glycol
  • S – Salicylates
More recently a new mnemonic has been suggested to update new our understanding of anion-gap generating acids. The updated mnemonic “GOLD MARK” was proposed in a 2008 article in The Lancet.
  • G – Glycols (ethylene glycol and propylene glycol)
  • O – Oxoproline
  • L – L-Lactate
  • D – D-Lactate
  • M – Methanol
  • A – Aspirin
  • R – Renal Failure
  • K – Ketoacidosis
As medicine evolves, so do our Mnemonics. This is the fifth medical mnemonic in our series of Monday Mnemonics.

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