The best tattoo numbing creams can be used on most parts of the body, but it's important to be cautious when applying them to sensitive areas. Avoid applying the cream to areas with broken or irritated skin, and be careful when applying it to areas with thin or delicate skin, such as the face or genitals. It's also important to follow the instructions on the cream carefully and not exceed the recommended dosage, as this can be harmful. If you're not sure whether it's safe to use numbing cream on a specific area of the body, consult with your tattoo artist or healthcare provider beforehand.