The adenosine receptors (ARs) in the nervous system act as a kind of "go-between" to regulate the release of neurotransmitters and the action of neuromodulators. Receptor-receptor interactions and AR-transporter interplay occur as part of the adenosine's attempt to control synaptic transmission. A2A receptor (A2AR) is highly expressed throughout the brain and A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases. A2AR is highly enriched in striatopallidal neurons and can form functional heteromeric complexes with other G-protein-coupled receptors, including dopamine D2, metabotropic glutamate mGlu5, and adenosine A1 receptors. It has emerged as an attractive non-dopaminergic target in the pursuit of improved therapy for Parkinson's disease (PD).

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