USMLE Step 1 Sample Question   The 72-year-old patient had prior elective aortic aneurysm resection but returned to a surgeon with the unusual complaint that both lower legs fell asleep when he had been kneeling on a church bench. Physical …
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  Kawasaki disease (mucocutaneous lymph node syndrome) is a rare childhood disease that causes inflammation in the walls of small-sized and medium sized arteries. It is most often seen in children under the age of 5 of Asian descent (primarily …
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MKSAP 16 Books Review   You may have already come across Knowmedge’s coverage of several other ABIM Internal Medicine Board Review books. Today, we explore the “big daddy of them all”—the Medical Knowledge Self-Assessment Program (MKSAP), created by the venerable …
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A 17-year-old high school student had been recently experiencing visual problems. When questioned by the physician, she mentioned that she had stopped menstruating several months previously. A MRI-scan of her head showed an abnormal mass just inferior to the hypothalamus. …
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  There are four types of hypersensitivity reactions. Type I is IgE-mediated and occurs very quickly after exposure. It is associated with allergens such as bee stings, peanuts, and certain medications, to name a few. This can lead to a …
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USMLE Step 1 Practice Question: Pharmacology   To achieve a loading dose of a drug where the volume of distribution of the drug is 35 L and the clearance rate is 70 ml/min, and the desired dose is 3.5 mg/L, …
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Medical Mnemonic of the Week: Normal Pressure Hydrocephalus (“Wacky, Wobbly, Wet”)     Patients who present with the triad of urinary incontinence, wide-based gait and dementia are likely to have normal pressure hydrocephalus (NPH). Symptoms for these patients are often …
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As we enter 2014, we wanted to take a moment and recap the eventful year we had here at Knowmedge! It’s not easy to recap everything that’s happened in our first year but we want to do our best to …
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USMLE STEP 1 Practice Question   Today we start a new feature on the blog with a focus on USMLE Step 1 Practice Questions. Here we have a two part physiology question:   An obese, pregnant, 26-year-old woman was seen …
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Medical Mnemonic of the Week: Rheumatic Fever (“JONES CAFE PAL”)     Rheumatic fever occurs after a streptococcal infection (usually caused by Group A Beta-Hemolytic Strep (GABHS)). It is an inflammatory condition that affects the joints, skin, heart and brain. …
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